CD-ROM
HUBUNGAN USIA DENGAN KADAR ANTIBODI S1RBD IMMUNOGLOBULIN G (IgG) PASCA VAKSINASI BOOSTER COVID-19 PADA CIVITAS AKADEMIKA POLTEKKES KEMENKES BANJARMASIN
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ABSTRAK
HUBUNGAN USIA DENGAN KADAR ANTIBODI S1RBD
IMMUNOGLOBULIN G (IgG) PASCA VAKSINASI BOOSTER COVID-19
PADA CIVITAS AKADEMIKA POLTEKKES KEMENKES
BANJARMASIN
Peneliti: Anisa Hariyanti
Pembimbing: Wahdah Norsiah, Tini Elyn Herlina
Corona Virus Disease 2019 (COVID-19) saat ini menjadi satu
permasalahan kesehatan di dunia dan terus meningkat secara global. Untuk
meredakan kasus ini, pemerintah di seluruh dunia mengusung program vaksinasi
untuk mengurangi morbiditas dan mortalitas untuk membentuk antibodi. Vaksinasi
booster COVID-19 dapat meningkatkan dan memperpanjang masa perlindungan
dalam tubuh. Salah satu faktor yang mempengaruhi respon imun adalah usia.
Semakin bertambahnya usia, kemampuan untuk produksi antibodi menurun yang
dihasilkan oleh sel limfosit B dan afinitas antibodi terhadap antigen sebagai respon
terhadap virus. Tujuan penelitian ini untuk mengetahui hubungan usia dengan kadar
antibodi pasca vaksinasi booster pada civitas akademika Poltekkes Kemenkes
Banjarmasin. Penelitian ini bersifat survei analitik dengan rancangan cross
sectional. Populasi pada penelitian ini adalah seluruh civitas akademik Poltekkes
Kemenkes Banjarmasin yang sudah melakukan vaksinasi booster COVID-19.
Sampel diambil dengan teknik purposive sampling dengan jumlah responden
sebanyak 30. Antibodi S1RBD diuji dengan alat ELISA dan kuesioner digunakan
untuk mengumpulkan data penelitian. Kelompok usia dibagi menjadi 3 yaitu 17-25
tahun, 26-45 tahun, dan 46-55 tahun. Kadar antibodi tertinggi ditemukan pada
kelompok usia 17-25 tahun dengan rata-rata 270.355 IU/mL dan rata-rata terendah
ditemukan pada kelompok usia 46-55 tahun yaitu 197.245 IU/mL. Berdasarkan
hasil analisis menggunakan uji Spearman’s rho menunjukkan bahwa hubungan usia
dengan kadar antibodi S1RBD IgG COVID-19 (p= -0,575) dan (r= 0,001) yang
artinya ada hubungan yang kuat dan arah hubungan yang negatif antar variabel.
Saran bagi peneliti selanjutnya untuk dapat mengidentifikasi lebih rinci respon
imun pasca vaksinasi booster COVID-19 pada kelompok lanjut usia.
Kata kunci: Usia, S1RBD IgG, COVID-19, Vaksinasi.
ix
ABSTRACT
THE RELATIONSHIP BETWEEN AGE AND S1RBD IMMUNOGLOBULIN
G (IgG) ANTIBODY LEVELS AFTER COVID-19 BOOSTER VACCINATION
IN THE POLTEKKES ACADEMIC COMMUNITY OF THE MINISTRY OF
HEALTH BANJARMASIN
Resercher: Anisa Hariyanti
Supervisors: Wahdah Norsiah, Tini Elyn Herlina
Corona Virus Disease 2019 (COVID-19) is currently a health problem in
the world and continues to increase globally. To reduce this case, governments
around the world carry out vaccination programs to reduce morbidity and mortality
to form antibodies. COVID-19 booster vaccination can increase and extend the
period of protection in the body. One factor that affects the immune response is age.
With age, the ability to produce antibodies decreases produced by B lymphocyte
cells and the affinity of antibodies to antigens in response to viruses. The purpose
of this study was to determine the relationship between age and antibody levels
after booster vaccination in the academic community of Poltekkes Kemenkes
Banjarmasin. This research is an analytical survey with a cross sectional design.
The population in this study is the entire academic community of the Banjarmasin
Ministry of Health Poltekkes who have carried out COVID-19 booster vaccinations.
The sample was taken by purposive sampling technique with a total of 30
respondents. S1RBD antibodies were tested with an ELISA tool and questionnaires
were used to collect research data. The age group is divided into 3, namely 17-25
years, 26-45 years, and 46-55 years. The highest antibody levels were found in the
age group of 17-25 years with an average of 270,355 IU / mL and the lowest
average was found in the age group of 46-55 years which was 197,245 IU / mL.
Based on the results of the analysis using Spearman's rho test, it shows that the
relationship between age and COVID-19 S1RBD IgG antibody levels (p = -0.575)
and (r = 0.001) which means that there is a strong relationship and a negative
relationship direction between variables. Suggestions for future researchers to be
able to identify in more detail the immune response after COVID-19 booster
vaccination in the elderly group.
Keywords: Age, Antibodies, IgG, COVID-19, vaccination.
Detail Information
| Item Type | |
|---|---|
| Penulis |
Anisa Hariyanti - Personal Name
Wahdah Norsiah, M.Si - Personal Name Tini Elyn Herlina - Personal Name |
| Student ID | |
| Dosen Pembimbing | |
| Penguji | |
| Kode Prodi PDDIKTI | |
| Edisi | |
| Departement | |
| Kontributor | |
| Bahasa |
Indonesia
|
| Penerbit | Jurusan Analis Kesehatan : Banjarbaru., 2023 |
| Edisi | |
| Subyek | |
| No Panggil |
005 SKP/ TLM 2023
|
| Copyright | |
| Doi |