File (Flashdisk)
Gambaran Hasil Skrining Talasemia pada Remaja di MAN Kota Banjarbaru Tahun 2024
- Bagikan:
ABSTRAK
Gambaran Hasil Skrining Talasemia pada Remaja di MAN Kota Banjarbaru
Tahun 2024
Peneliti : Nor Asrina Elva
Pembimbing : Nurlailah, Neni Oktiyani
Talasemia merupakan penyakit hemolitik herediter yang disebabkan oleh gangguan
sintesis hemoglobin di dalam sel darah merah sehingga mengakibatkan riwayat anemia,
sering sakit, pucat, gejala merasa cepat lelah dan lesu. Talasemia dibedakan dengan
perhitungan Indeks Mentzer yang dihitung dari MCV dibagi RBC jika nilai <13 dan
Red Cell Distribution Width nilai >14 maka terindikasi talasemia minor. Tujuan
penelitian ini adalah untuk mengetahui Gambaran Hasil Skrining Talasemia pada
Remaja di MAN Kota Banjarbaru. Jenis penelitian ini adalah survey deskriptif dengan
pendekatan cross sectional. Populasi pada penelitian ini sebanyak 80 siswa MAN Kota
Banjarbaru kelas XII yang dipilih dengan teknik purposive sampling menjadi 30
subjek. Skrining talasemia dilakukan dengan pemeriksaan Kadar Hemoglobin, Indeks
Eritrosit, Indeks Mentzer, Red Cell Distribution Width dan Morfologi Entrosit.
Berdasarkan hasil pemeriksaan kadar hemoglobin pada subjek penelitian terdapat 27
subjek (77%) termasuk anemia derajat sedang dan ringan berdasarkan kadar
hemoglobin untuk diagnosis anemia (WHO, 2011). Hasil dari indeks eritrosit pada
subjek terdapat nilai MCV yang abnormal sebanyak 4 subjek (17%), nilai MCH yang
abnormal sebanyak 28 subjek (93%), dan MCHC yang abnormal sebanyak 21 subjek
(70%). Dengan rata-rata hasil MCV adalah 83,6 fl., MCH adalah 24,6 pg, dan MCHC
adalah 29,4 g/dl. Frekuensi terduga talasemia beta minor sebanyak 1 subjek (3%)
berdasarkan perhitungan dengan Indeks Mentzer dan pemeriksaan Red Cell
Distribution Width. Kesimpulan penelitian terdapat 1 subjek (3%) dengan indikasi
talasemia dengan anemia mikrositik hipokromik ditemukan bentuk teardrop cell, burr
cell, eliptosit, sperosit, dan pencil cell. Saran peneliti selanjutnya dianjurkan
melanjutkan pemeriksaan pada orang tua dan saudara kandung dari subyek penelitian
yang positif terindikasi talasemia sehingga dapat terbentuk pedigree penyebaran
talasemia serta dilanjutkan dengan pemeriksaan elektroforesis hemoglobin, kadar besi,
dan kadar ferritin serum.
Kata Kunci : Skrining Talasemia, Remaja
ix
ABSTRACT
Description of Thalassemia Screening Results in Adolescents at MAN
Banjarbaru City in 2024
Researcher: Nor Asrina Elva
Advisor: Nurlailah, Neni Oktiyani
Thalassemia is a hereditary hemolytic disease caused by impaired hemoglobin
synthesis in red blood cells, resulting in a history of anemia, frequent illness, paleness,
symptoms of feeling tired and lethargic. Thalassemia is differentiated by calculating
the Mentzer Index which is calculated from MCV divided by RBC if the value is <13
and the Red Cell Distribution Width value is >14, then thalassemia minor is indicated.
The aim of this research is to determine the description of the results of thalassemia
screening in adolescents in MAN, Banjarbaru City. This type of research is a
descriptive survey with a cross sectional approach. The population in this study was 80
students of MAN Banjarbaru City class XII who were selected using a purposive
sampling technique to become 30 subjects. Thalassemia screening is carried out by
examining Hemoglobin Levels, Erythrocyte Index, Mentzer Index, Red Cell
Distribution Width and Entrocyte Morphology. Based on the results of examining
hemoglobin levels in research subjects, there were 27 subjects (77%) including
moderate and mild anemia based on hemoglobin levels for diagnosing anemia (WHO,
2011). The results of the erythrocyte index in the subjects showed abnormal MCV
values in 4 subjects (17%), abnormal MCH values in 28 subjects (93%), and abnormal
MCHC in 21 subjects (70%). With an average MCV result of 83.6 fl., MCH was 24.6
pg, and MCHC was 29.4 g/dl. The frequency of suspected beta thalassemia minor was
1 subject (3%) based on calculations using the Mentzer Index and Red Cell Distribution
Width examination. The conclusion of the study was that there was 1 subject (3%) with
indications of thalassemia with hypochromic microcytic anemia found in the form of
teardrop cells, burr cells, elliptocytes, sperocytes and pencil cells. The researcher's next
suggestion is to continue examining the parents and siblings of research subjects who
are positive for thalassemia so that a pedigree for the spread of thalassemia can be
established and continue with examination of hemoglobin electrophoresis, iron levels
and serum ferritin levels.
Keywords : Thalassemia Screening, Adolescents
Detail Information
| Item Type | |
|---|---|
| Penulis |
Nor Asrina Elva - Personal Name
Dra. Nurlailah, Apt., M.Si. - Personal Name Neni Oktiyani, M.Sc - Personal Name |
| Student ID | |
| Dosen Pembimbing | |
| Penguji | |
| Kode Prodi PDDIKTI | |
| Edisi | |
| Departement | |
| Kontributor | |
| Bahasa |
Indonesia
|
| Penerbit | Jurusan Analis Kesehatan : Banjarbaru., 2024 |
| Edisi | |
| Subyek | |
| No Panggil |
KTI TLM 050/2024
|
| Copyright | |
| Doi |