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PERBANDINGAN HASIL DIAGNOSIS LABORATORIUM PADA COVID-19 MENGGUNAKAN METODE REAL TIME-POLYMERASE CHAIN REACTION (RT-PCR) DAN METODE RAPID TEST ANTIGEN
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ABSTRAK
PERBANDINGAN HASIL DIAGNOSIS LABORATORIUM PADA COVID-19
MENGGUNAKAN METODE REAL TIME-POLYMERASE CHAIN REACTION
(RT-PCR) DAN METODE RAPID TEST ANTIGEN
Peneliti : Rahmadhaniati
Pembimbing : Dinna Rakhmina, Tini Elyn Herlina
Penyakit Coronavirus 2019 (COVID-19) adalah merupakan krisis kesehatan
dunia. Dalam mendiagnosis COVID-19 digunakan beberapa metode, salah
satunya adalah RT-PCR dan Rapid Test Antigen. Penelitian ini bertujuan untuk
membandingkan nilai sensitivitas dan spesifisitas antara metode RT-PCR dan
metode Rapid Test Antigen. Tinjauan literatur ini didapatkan dari tiga database
(Pubmed, Science Direct, dan Google Scholar) dan pencarian literatur dilakukan
pada bulan oktober tahun 2020. Untuk menguji kelayakan studi digunakan MeSH
dan prisma cheklist (judul, abstrak, dan teks lengkap). Penyajian dibuat dalam
bentuk tabulasi data dan analisis naratif. Dari penelitian ini didapatkan dua belas
studi yang memenuhi kriteria inklusi. Studi yang ada dibagi menjadi dua bagian
berdasarkan tema: sensitivitas spesifisitas dari metode RT-PCR dan sensitivitas
spesifisitas dari metode rapid test antigen (n=10) serta sensitivitas spesifisitas dari
metode rapid test antigen (n=2). Adapun faktor yang mempengaruhi pemeriksaan
metode RT-PCR : gender, gejala, penentuan nilai Ct, nilai sensitivitas, kendala
logistik. Sedangkan faktor yang mempengaruhi dalam pemeriksaan metode rapid
test antigen adalah jenis sampel, petugas pengambil swab, lama pajanan,
kandungan virus, dan faktor pengganggu lainnya. Didapatkan nilai sensitivitas
RT-PCR, Rapid Test Antigen adalah 50,5%-100%,11,7%-93,9%. Spesifisitas RTPCR, Rapid Test Antigen adalah 98,4%-100%, 92%-100%. RT-PCR lebih baik
dan lebih tinggi nilai sensitivitas dan spesifisitasnya dari Rapid Test Antigen.
Kata kunci : Diagnosa Laboratorium COVID-19, RT-PCR, Rapid Test Antigen,
Sensitivitas dan Spesifisitas.
ABSTRACT
COMPARISON OF COVID-19 LABORATORY DIAGNOSIS RESULTS
USING RAPID TEST ANTIGEN METHODS AND REAL TIMEPOLYMERASE CHAIN REACTION (RT-PCR)
Researcher: Rahmadhaniati
Advisors: Dinna Rakhmina, Tini Elyn Herlina
The 2019 Coronavirus Outbreak (COVID-19) is a global health emergency.
Several methods are used to diagnose COVID-19, including the RT-PCR and the
Rapid Antigen Test. The aim of this analysis is to compare the sensitivity and
specificity of the RT-PCR and the Rapid Antigen Test methods. The information
for this study came from three sources (Pubmed, Science Direct, and Google
Scholar), and a literature search was conducted in October 2020. MeSH and a
checklist prism were used to see if the analysis was feasible (title, abstract, and
full text). The data is tabulated and a narrative analysis is used to present the
information. Twelve studies met the inclusion criteria as a result of this study. The
existing study is divided into two parts based on the theme: sensitivity, specificity
of the RT-PCR method and the sensitivity, specificity of the antigen rapid test
method(n=10) and the sensitivity, specificity of the antigen rapid test
method(n=2). Sex, symptoms, Ct value determination, sensitivity values, and
logistical constraints are some of the factors that influence the analysis of the RTPCR process. Meanwhile, the type of sample, the officer who takes the swab, the
duration of exposure, the virus material, and other confounding factors all affect
the rapid test antigen method's review. The sensitivity values for the Rapid
Antigen Test using RT-PCR were 50.5% -100% and 11.7%-93.9%. The Rapid
Antigen Test by RT-PCR has a specificity of 98.4%-100% and a 92%-100%. The
RT-PCR is superior to the Rapid Antigen Test in terms of sensitivity and
specificity.
Key words: Laboratory Diagnostic COVID-19, RT-PCR, Rapid Antigen Test,
Sensitivity and Specificity.
Detail Information
| Item Type | |
|---|---|
| Penulis | |
| Student ID | |
| Dosen Pembimbing | |
| Penguji | |
| Kode Prodi PDDIKTI | |
| Edisi | |
| Departement | |
| Kontributor | |
| Bahasa |
Indonesia
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| Penerbit | Jurusan Analis Kesehatan : Banjarbaru., 2021 |
| Edisi | |
| Subyek | |
| No Panggil |
ANK.21/SKP-2021
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| Copyright | |
| Doi |