Jujuk Anton Cahyono Dosen Pembimbing 1 Wahdah Norsiah Dosen Pembimbing 2 Khairurrahmatil ‘Ulya Pengarang

ABSTRAK Perbandingan Kadar High Density Lipoprotein (HDL) pada Serum Segera dengan Serum Tunda 1 Jam, 2 Jam dan 3 Jam Peneliti : Khairurrahmatil ‘Ulya Pembimbing : Jujuk Anton Cahyono, Wahdah Norsiah Kadar High Density Lipoprotein (HDL) yang optimal dalam darah bersifat protektif terhadap penyakit jantung, penurunan kadar HDL dapat meningkatkan risiko terjadinya penyakit jantung. Pemeriksaan kolesterol HDL kadang kala tidak dapat segera dilakukan atau terpaksa ditunda apabila terjadi kendala saat pemeriksaan. Apabila proses pemeriksaan kolesterol HDL tertunda maka akan terjadi perubahan fraksi-fraksi lipoprotein. Penelitian ini bertujuan untuk mengetahui perbedaan kadar kolesterol High Density Lipoprotein (HDL) pada serum segera dengan serum tunda 1 jam, 2 jam dan 3 jam. Penelitian ini bersifat quasi experiment, rancangan yang digunakan yaitu Postest Only With Control Group Design. Hasil pemeriksaan kadar kolesterol HDL yang dilakukan menunjukkan rata-rata kadar kolesterol HDL sampel serum yang telah disentrifugasi dan ditunda suhu ruang pada waktu 0 jam (tanpa penundaan), 1 jam, 2 jam dan 3 jam secara berurutan yaitu 47,46 mg/dl, 44,36 mg/dl, 40,58 mg/dl, 36,65 mg/dl. Berdasarkan hasil uji Repeated Measures Anova didapatkan signifikasi = 0,000 (<0,05) yang menandakan adanya perbedaan yang signifikan antara kadar kolesterol HDL yang diperiksa segera dengan yang ditunda 1 jam, 2 jam dan 3 jam. Adapun saran bagi peneliti selanjutnya dapat menggunakan serum pada pasien wanita menopause yang memiliki resiko Penyakit Jantung Koroner yang dirawat dirumah sakit. Kata Kunci : High Density Lipoprotein (HDL), serum dan waktu penundaan. ABSTRACT Comparison of High Density Lipoprotein (HDL) Levels in Immediate Serum with 1 hour, 2 hours and 3 hours Delay Serum. Author : Khairurrahmatil ‘Ulya Advisors : Jujuk Anton Cahyono, Wahdah Norsiah Optimal levels of High Density Lipoprotein (HDL) in the blood are protective against heart disease, a decrease in HDL levels can increase the risk of heart disease. HDL cholesterol checks can sometimes not be done immediately or forced to be postponed if there are obstacles during the examination. If the HDL cholesterol check process is delayed there will be changes in lipoprotein fractions. This study aims to determine differences in cholesterol levels of High Density Lipoprotein (HDL) in serum immediately with serum delay of 1 hour, 2 hours and 3 hours. This research is a quasi experiment, the design used is Postest Only With Control Group Design. The results of HDL cholesterol tests carried out showed the average HDL cholesterol levels of serum samples that had been centrifuged and delayed at room temperature at 0 hour (without delay), 1 hour, 2 hours and 3 hours in a row that is 47.46 mg / dl, 44.36 mg / dl, 40.58 mg / dl, 36.65 mg / dl. Based on the Anova Repeated Measures test results obtained significance = 0,000 (<0.05) which indicates a significant difference between HDL cholesterol levels checked immediately with those delayed by 1 hour, 2 hours and 3 hours. As for suggestions for further researchers can use serum in hospitalized menopausal female patients who have a risk of coronary heart disease. Keywords : High Density Lipoprotein (HDL), serum and time delay.