Ratih Dewi Dwiyanti Dosen Pembimbing 1 Aima Insana Dosen Pembimbing 2 Fatimah Khalda Pengarang

ABSTRAK HUBUNGAN FREKUENSI LAMA MEROKOK DENGAN KEJADIAN TUBERKULOSIS (TBC) PADA PASIEN RAWAT INAP DI RUANG ISOLASI RSUD DATU SANGGUL Peneliti : Fatimah Khalda Pembimbing : Ratih Dewi Dwiyanti, Aima Insana Tuberkulosis (TB) adalah salah satu penyakit infeksi tertua yang melekat sepanjang sejarah peradaban manusia dan masih menjadi masalah kesehatan masyarakat.Tes Cepat Molekuler (TCM) merupakan alat diagnosis utama yang mempunyai sensitivitas dan spesifisitas yang jauh lebih baik untuk diagnosis TB dibandingkan pemeriksaan mikroskopis serta mendekati kualitas diagnosis dengan pemeriksaan biakan. Merokok tembakau dapat mempengaruhi sistem kekebalan tubuh dengan menyebabkan defek pada sel imun seperti makrofag, monosit dan limfosit CD4 (kluster diferensiasi 4). Tujuan penelitian untuk mengetahui pengaruh frekuensi merokok dengan kejadian TB pada pasien rawat inap di ruang isolasi RSUD Datu Sanggul. Jenis penelitian Survey Analitik dengan rancangan penelitian Cross Sectional. Populasi penelitian ini adalah pasien TB yang melakukan pemeriksaan TCM di ruang rawat inap isolasi RSUD Datu Sanggul periode 15 Juni – 15 September 2023 sebanyak 45 sampel. Pengambilan sampling dengan teknik total sampling. Hasil penelitian didapatkan hasil tidak terdeteksi MTB sebanyak 15 sampel, dan terdeteksi MTB sebanyak 30 sampel (5 hasil MTB deteceted very low, 11 hasil MTB detected low, 6 hasil MTB detected medium, 8 hasil MTB detected high). Lembar kuesioner menunjukkan >50% responden belum mengetahui tentang pengetahuan dan faktor resiko, dan hubungan frekuensi lama merokok dari hasil lembar kuesioner tentang lama merokok di dapatkan <10 tahun 2 orang (8%) dam >10 tahun di dapatkan 24 orang (92%) dengan klasifikasi merokok ringan 2 orang (8%), klasifikasi sedang 16 orang (62%), klasifikasi berat 5 orang (19%), dan klasifikasi sangat berat 3 orang (11%). Saran untuk peneliti selanjutnya dapat meneliti hubungan pada kategori pasien berbeda seperti terduga TB dengan riwayat penyakit bawaan seperti HIV/AIDS, DM, ginjal kronis. Kata Kunci : Tuberkulosis, Tes Cepat Molekuler, Merokok ix ABSTRACT THE RELATIONSHIP BETWEEN THE FREQUENCY OF SMOKING AND THE OCCURRENCE OF TUBERKULOSIS (TB) IN INPATIENTS IN THE ISOLATION WARD OF DATU SANGGUL REGIONAL HOSPITAL Researcher : Fatimah Khalda Advisor : Ratih Dewi Dwiyanti, Aima Insana Tuberculosis (TB) is one of the oldest infectious diseases in human history and remains a public health problem. The Molecular Rapid Test (MRT) is the main diagnostic tool with better sensitivity and specificity for diagnosing TB compared to microscopic examination and approaches the quality of diagnosis with culture examination. Tobacco smoking can affect the immune system by causing defects in immune cells such as macrophages, monocytes, and CD4 lymphocytes (cluster of differentiation 4). The purpose of this study was to determine the effect of smoking frequency on the occurrence of TB in inpatients in the isolation ward of Datu Sanggul Regional Hospital. This was an analytic survey with a cross-sectional research design. The study population consisted of TB patients who underwent MRT examination in the isolation ward of Datu Sanggul Regional Hospital from June 15th to September 15th, 2023, with a total of 45 samples. Sampling was done using total sampling technique. The results showed that TB was not detected in 15 samples, while it was detected in 30 samples (5 had very low TB detection, 11 had low TB detection, 6 had medium TB detection, and 8 had high TB detection). The questionnaire sheets indicated that >50% of respondents did not have knowledge about risk factors and the relationship between smoking frequency and TB occurrence. From the questionnaire, it was found that 2 individuals (8%) had smoked for less than 10 years, while 24 individuals (92%) had smoked for more than 10 years, with 2 individuals classified as light smokers (8%), 16 as moderate smokers (62%), 5 as heavy smokers (19%), and 3 as very heavy smokers (11%). It is suggested that future research should investigate the relationship in different patient categories, such as suspected TB patients with underlying conditions like HIV/AIDS, diabetes mellitus, or chronic kidney disease. Keywords : Tuberculosis, Molecular Rapid Test, Smoke