Tini Elyn Herlina Dosen Pembimbing 2 Wahdah Norsiah, M.Si Dosen Pembimbing 1 Anisa Hariyanti Pengarang

ABSTRAK HUBUNGAN USIA DENGAN KADAR ANTIBODI S1RBD IMMUNOGLOBULIN G (IgG) PASCA VAKSINASI BOOSTER COVID-19 PADA CIVITAS AKADEMIKA POLTEKKES KEMENKES BANJARMASIN Peneliti: Anisa Hariyanti Pembimbing: Wahdah Norsiah, Tini Elyn Herlina Corona Virus Disease 2019 (COVID-19) saat ini menjadi satu permasalahan kesehatan di dunia dan terus meningkat secara global. Untuk meredakan kasus ini, pemerintah di seluruh dunia mengusung program vaksinasi untuk mengurangi morbiditas dan mortalitas untuk membentuk antibodi. Vaksinasi booster COVID-19 dapat meningkatkan dan memperpanjang masa perlindungan dalam tubuh. Salah satu faktor yang mempengaruhi respon imun adalah usia. Semakin bertambahnya usia, kemampuan untuk produksi antibodi menurun yang dihasilkan oleh sel limfosit B dan afinitas antibodi terhadap antigen sebagai respon terhadap virus. Tujuan penelitian ini untuk mengetahui hubungan usia dengan kadar antibodi pasca vaksinasi booster pada civitas akademika Poltekkes Kemenkes Banjarmasin. Penelitian ini bersifat survei analitik dengan rancangan cross sectional. Populasi pada penelitian ini adalah seluruh civitas akademik Poltekkes Kemenkes Banjarmasin yang sudah melakukan vaksinasi booster COVID-19. Sampel diambil dengan teknik purposive sampling dengan jumlah responden sebanyak 30. Antibodi S1RBD diuji dengan alat ELISA dan kuesioner digunakan untuk mengumpulkan data penelitian. Kelompok usia dibagi menjadi 3 yaitu 17-25 tahun, 26-45 tahun, dan 46-55 tahun. Kadar antibodi tertinggi ditemukan pada kelompok usia 17-25 tahun dengan rata-rata 270.355 IU/mL dan rata-rata terendah ditemukan pada kelompok usia 46-55 tahun yaitu 197.245 IU/mL. Berdasarkan hasil analisis menggunakan uji Spearman’s rho menunjukkan bahwa hubungan usia dengan kadar antibodi S1RBD IgG COVID-19 (p= -0,575) dan (r= 0,001) yang artinya ada hubungan yang kuat dan arah hubungan yang negatif antar variabel. Saran bagi peneliti selanjutnya untuk dapat mengidentifikasi lebih rinci respon imun pasca vaksinasi booster COVID-19 pada kelompok lanjut usia. Kata kunci: Usia, S1RBD IgG, COVID-19, Vaksinasi. viii ABSTRACT THE RELATIONSHIP BETWEEN AGE AND S1RBD IMMUNOGLOBULIN G (IgG) ANTIBODY LEVELS AFTER COVID-19 BOOSTER VACCINATION IN THE POLTEKKES ACADEMIC COMMUNITY OF THE MINISTRY OF HEALTH BANJARMASIN Resercher: Anisa Hariyanti Supervisors: Wahdah Norsiah, Tini Elyn Herlina Corona Virus Disease 2019 (COVID-19) is currently a health problem in the world and continues to increase globally. To reduce this case, governments around the world carry out vaccination programs to reduce morbidity and mortality to form antibodies. COVID-19 booster vaccination can increase and extend the period of protection in the body. One factor that affects the immune response is age. With age, the ability to produce antibodies decreases produced by B lymphocyte cells and the affinity of antibodies to antigens in response to viruses. The purpose of this study was to determine the relationship between age and antibody levels after booster vaccination in the academic community of Poltekkes Kemenkes Banjarmasin. This research is an analytical survey with a cross sectional design. The population in this study is the entire academic community of the Banjarmasin Ministry of Health Poltekkes who have carried out COVID-19 booster vaccinations. The sample was taken by purposive sampling technique with a total of 30 respondents. S1RBD antibodies were tested with an ELISA tool and questionnaires were used to collect research data. The age group is divided into 3, namely 17-25 years, 26-45 years, and 46-55 years. The highest antibody levels were found in the age group of 17-25 years with an average of 270,355 IU / mL and the lowest average was found in the age group of 46-55 years which was 197,245 IU / mL. Based on the results of the analysis using Spearman's rho test, it shows that the relationship between age and COVID-19 S1RBD IgG antibody levels (p = -0.575) and (r = 0.001) which means that there is a strong relationship and a negative relationship direction between variables. Suggestions for future researchers to be able to identify in more detail the immune response after COVID-19 booster vaccination in the elderly group. Keywords: Age, Antibodies, IgG, COVID-19, vaccination.